The Effect of Vegetable and Volatile Oils on the Piroxicam Skin Permeability: A Mechanistic Study

Background: Piroxicam is a non-steroidal anti-inflammatory medication for treating fever, discomfort, and inflammation. In addition, piroxicam inhibits cyclooxygenase lowers prostaglandin synthesis, resulting in analgesic effects. Objectives: This study used Franz diffusion cells made from rat skin primed with sesame, eucalyptus, olive, menthol, clove, sunflower oils. Methods: Control was hydrated skin. Permeability measurements include steady-state flux (Jss), permeability coefficient (Kp), (D). FT-IR to compare changes peak position, differential scanning calorimeter (DSC), mean transition temperature, the enhancement methods of penetration enhancer (Tm). The acted as barrier throughout whole surface, indicating that drug limited by into Results: (Jss) all enhancers were not significantly different control, except clove menthol oil (4 hours treated) olive (2 4 treated). Conclusions: Penetration improved through Sesame oil, sesame found have higher ERflux, ERD, ERP ratios than water-hydrated due lipid fluidization, structure disruption, irreversible keratin denaturation.